Endocrine Abstracts

Three premenopausal patients presented with high isolated testosterone without symptoms of androgen excess or illicit drug use.Case 1: A 22-year-old female presented with daily vaginal bleeds having been on depot injections of progesterone with supplementary norethisterone. Testosterone was 14.5 nmol/l with suppressed gonadotrophins (LH <0.1 IU/l, FSH 0.2 IU/l, oestradiol <19 pmol/l). Her norethisterone was stopped. A repeat biochemical profile a...

Cranial Diabetes Insipidus (CDI) is associated with significant polyuria and is treated with desmopressin. Inappropriate or missed treatment can result in significant electrolyte imbalance and potential harm. A recent UK survey of Endocrinologists reported 55% had concerns about knowledge in their trust, 39% felt they had observed patients come to harm. Patients not receiving desmopressin have been associated with death, leading to an NHS England (NHSE) safety alert in 2016. W...